Thermo Fisher Scientific RELM beta Polyclonal Antibody
RELM beta 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. Western blot 및 IHC(P) 검증 완료. 고순도 액상 형태로 제공되며, 인체 시료에 반응. 지방조직 관련 연구 및 당뇨병 기전 연구에 적합.
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- PA518956
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- pk
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Thermo Fisher Scientific RELM beta Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (DSVMDKKIKDVLNS) corresponding to internal amino acids of RETNLB (aa 28–42) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982509 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
Adipose tissue functions as a tightly regulated energy reserve, producing and secreting various physiologically important proteins such as lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine secreted specifically by adipocytes. It plays a paracrine role and is implicated in type 2 diabetes.
In obese, diabetic mice, serum resistin levels are elevated, antagonizing insulin action and contributing to insulin resistance and glucose intolerance.
Resistin gene expression depends on C/EBP alpha and is influenced by coactivators CBP and p300, which acetylate histones at the resistin promoter. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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