Thermo Fisher Scientific DIO3 Polyclonal Antibody
DIO3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 인간, 마우스, 랫드 등 다양한 종에 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DIO3 (Accession P55073), corresponding to amino acid residues V117–V141 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852497 |
Product Specific Information
This antibody detects endogenous levels of total DIO3.
Target Information
DIO3 (Type III iodothyronine deiodinase) belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormones by inner ring deiodination of thyroxine (T4) and triiodothyronine (T3), producing inactive metabolites reverse T3 (rT3) and T2.
This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, indicating its essential role in thyroid hormone regulation during embryonic development.
DIO3 contains a selenocysteine (Sec) residue, critical for enzyme activity. The Sec residue is encoded by the UGA codon, which typically signals translation termination. The 3′ UTR of Sec-containing genes includes a SECIS (selenocysteine insertion sequence) element that allows UGA to be recognized as a Sec codon instead of a stop signal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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