Thermo Fisher Scientific SH3BP4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SH3BP4. Recombinant protein control fragment (Product #RP-102773). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SH3BP4,uniProtId:Q9P0V3-1,ncbiNodeId:9606,antigenRange:537-636,antigenLength:963,antigenImageFileName:PA5-57993_SH3BP4_Q9P0V3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57993_SH3BP4_Q9P0V3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647238

Product Specific Information

Immunogen sequence: LKVCMFSNMT NYEVKASEQA KVVRGFQLKL GKVSRLIFPI TSQNPNELSD FTLRVQVKDD QEAILTQFCV QTPQPPPKSA IKPSGQRRFL KKNEVGKIIL

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

Target Information

SH3BP4 was initially isolated as a novel cDNA using differential display analysis using cultured human corneal fibroblasts. The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. SH3BP4 has been shown to interact with specific endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR) and localizes to TfR-containing coated pits and vesicles. It is thought to be involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of TfR. At least two isoforms of SH3BP4 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.