Thermo Fisher Scientific SH3BP4 Polyclonal Antibody
Human SH3BP4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. SH3BP4 단백질의 세포 내 수송 및 내포화 연구에 적합.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SH3BP4 (Product # RP-102773) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647238 |
Product Specific Information
Immunogen sequence:
LKVCMFSNMT NYEVKASEQA KVVRGFQLKL GKVSRLIFPI TSQNPNELSD FTLRVQVKDD QEAILTQFCV QTPQPPPKSA IKPSGQRRFL KKNEVGKIIL
- Highest antigen sequence identity to orthologs:
- Mouse: 91%
- Rat: 91%
Target Information
SH3BP4 was initially isolated as a novel cDNA using differential display analysis from cultured human corneal fibroblasts.
The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site.
SH3BP4 interacts with endocytic proteins such as clathrin, dynamin, and the transferrin receptor (TfR), localizing to TfR-containing coated pits and vesicles.
It is involved in cargo-specific control of clathrin-mediated endocytosis, particularly in the internalization of TfR.
At least two isoforms of SH3BP4 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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