Thermo Fisher Scientific USP11 Polyclonal Antibody
Rabbit polyclonal antibody targeting human USP11 단백질. IHC(P)에서 1:200–1:500 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품으로, PBS 및 글리세롤 완충액에 보관. BRCA2 탈유비퀴틴화 연구에 유용.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human USP11. Recombinant protein control fragment (Product # RP-95437) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2649330 |
Product Specific Information
Immunogen sequence:
VEPQEDTRLW AKNSEGSLDR LYDTHITVLD AALETGQLII METRKKDGTW PSAQLHVMNN NMSEEDEDFK GQPGICGLTN LGNT
Highest antigen sequence identity to orthologs:
- Mouse: 82%
- Rat: 83%
Target Information
USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the ubiquitin pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and the tumor suppressor BRCA2. Through these interactions, USP11 functions to inhibit ubiquitination or remove ubiquitin residues from these proteins. It is implicated in several X-linked retinal diseases and may play a role in tumor suppression due to its BRCA2 deubiquitination activity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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