Thermo Fisher Scientific DOCK3 Polyclonal Antibody
Human DOCK3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. Alzheimer 연구 등 신경세포 신호전달 관련 연구에 활용 가능합니다.
- 카탈로그번호
- PA557996
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DOCK3. Recombinant protein control fragment (Product #RP-96295) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640738 |
Product Specific Information
Immunogen sequence:
FEVVDSDQIS VSDLYKMHLS SRQSVQQSTS QVDTMRPRHG ETCRMPVPHH FFLSLKSFTY NTIGEDTDVF FSLYDMREGK QISERFLVRL NKNG
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
Dedicator of cytokinesis 3 (DOCK3), also known as MOCA and PBP, is a ~180 kDa protein involved in signal transduction. It functions as a potential guanine nucleotide exchange factor (GEF) that activates small GTPases by exchanging GDP for GTP. DOCK3 is associated with Alzheimer’s disease tangles and regulates amyloid precursor protein and beta-amyloid accumulation.
Overexpression of DOCK3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. It binds and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays critical roles downstream of BDNF signaling in the CNS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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