Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), eFluor 450, eBioscience

Applications

• Flow Cytometry (Flow)
  • Tested Dilution: 5 µL (0.5 µg)/test
  • View 3 publications

Product Specifications

Additional Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• FITC
• NovaFluor Blue 510
• NovaFluor Blue 610-70S
• NovaFluor Red 710
• NovaFluor Yellow 590
• NovaFluor Yellow 610
• NovaFluor Yellow 660
• PE
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 780
• Request custom conjugation

Product Specific Information

The IP26 monoclonal antibody reacts with the alpha beta chain of human TCR, which is expressed by the majority of peripheral T cells.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Pre-diluted and tested for flow cytometric analysis of normal human peripheral blood cells
• Recommended usage: 5 µL (0.5 µg) per test in a final volume of 100 µL (cell number: 10⁵–10⁸ cells/test)

Fluorochrome Information:
eFluor 450 is an alternative to Pacific Blue, excited at 405 nm and emits at 446 nm. Ensure the instrument can detect this fluorochrome.

• Excitation: 405 nm
• Emission: 445 nm
• Laser: Violet

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, zeta). These are essential for surface expression and signal transduction.
TCR engagement triggers T cell activation, differentiation, and cytokine production.
Most T cells in blood and lymphoid organs express TCR alpha/beta, while gamma/delta T cells are mainly found in epithelial tissues.
Defects in TCR expression or signaling are associated with autoimmune diseases and immunodeficiencies.
TCR recognition of self-peptides is linked to autoimmunity; mutant self-peptides may be tumor-associated antigens.
Superantigen engagement of TCRs can lead to toxic shock syndrome.
Autoantibodies against TCR Vβ segments have been identified in rheumatoid arthritis and systemic lupus erythematosus, potentially modulating immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지