Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), eFluor 450, eBioscience
인간 TCR α/β 사슬을 인식하는 IP26 단클론 항체로, eFluor 450 형광체가 결합되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 405 nm에서 여기되어 445 nm에서 방출됩니다. 대부분의 말초 T세포 분석에 적합합니다.
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Applications
- Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.5 µg)/test
- View 3 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), eFluor™ 450, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IP26 |
| Conjugate | eFluor™ 450 |
| Excitation/Emission Max | 405/445 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2848397 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- FITC
- NovaFluor Blue 510
- NovaFluor Blue 610-70S
- NovaFluor Red 710
- NovaFluor Yellow 590
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
The IP26 monoclonal antibody reacts with the alpha beta chain of human TCR, which is expressed by the majority of peripheral T cells.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-diluted and tested for flow cytometric analysis of normal human peripheral blood cells
- Recommended usage: 5 µL (0.5 µg) per test in a final volume of 100 µL (cell number: 10⁵–10⁸ cells/test)
Fluorochrome Information:
eFluor 450 is an alternative to Pacific Blue, excited at 405 nm and emits at 446 nm. Ensure the instrument can detect this fluorochrome.
- Excitation: 405 nm
- Emission: 445 nm
- Laser: Violet
Target Information
The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 subunits (gamma, delta, eta, zeta). These are essential for surface expression and signal transduction.
TCR engagement triggers T cell activation, differentiation, and cytokine production.
Most T cells in blood and lymphoid organs express TCR alpha/beta, while gamma/delta T cells are mainly found in epithelial tissues.
Defects in TCR expression or signaling are associated with autoimmune diseases and immunodeficiencies.
TCR recognition of self-peptides is linked to autoimmunity; mutant self-peptides may be tumor-associated antigens.
Superantigen engagement of TCRs can lead to toxic shock syndrome.
Autoantibodies against TCR Vβ segments have been identified in rheumatoid arthritis and systemic lupus erythematosus, potentially modulating immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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