Thermo Fisher Scientific SCNN1G Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence:
  SEYGLQVILYI NEEEYNPFLV SSTGAKVIIH RQDEYPFVED VGTEIETAMV TSIGMHLTES FKLSEPYSQ
• Ortholog identity: Highest antigen sequence identity to mouse (90%) and rat (90%).

Target Information

Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarity, possessing two short intracellular amino and carboxyl termini, two short membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.

There are three homologous isoforms of ENaC (α, β, and γ). ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. It mediates aldosterone-dependent sodium reabsorption in the distal nephron, thereby regulating blood pressure. ENaC is also thought to be regulated through association with the CFTR chloride ion channel. Gain-of-function mutations in β- or γ-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in α- or β-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.