Thermo Fisher Scientific AXIN2 Recombinant Rabbit Monoclonal Antibody (JM11-30)
AXIN2 단백질을 인식하는 재조합 토끼 단클론 항체로, WB 및 IHC(P) 분석에 적합합니다. HEK293 세포에서 발현되었으며 높은 특이성과 로트 간 일관성을 제공합니다. 단백질 A로 정제된 액상 항체로 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:10–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM11-30 |
| Immunogen | Synthetic peptide within Human Axin2 aa 55–93 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809923 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Axin-related protein Axin2 plays a key role in regulating beta-catenin stability in the Wnt signaling pathway, similar to its rodent homologs (mouse conductin/rat axil). In mouse, conductin organizes a multiprotein complex including APC, beta-catenin, glycogen synthase kinase 3-beta, and conductin, leading to beta-catenin degradation.
Deregulation of beta-catenin is an important event in various malignancies. The AXIN2 gene, mapped to 17q23–q24, shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in AXIN2 are associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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