Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI1C8), TrueMAB
Human N4BP2L2 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 IHC(P) 실험에 적합함. TrueMAB 포맷으로 높은 특이성과 재현성을 제공하며, 액상 형태로 1 mg/mL 농도 유지. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:200
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C8 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein that may be involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser199 in response to DNA damage, probably by ATM or ATR. It is primarily expressed in bone marrow and is significantly down-regulated after exposure to arsenic compounds, preceding neutropenia. PFAAP5 interacts with both Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene encoding Neutrophil Elastase cause cyclic haematopoiesis, leading to reduced neutrophil counts and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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