Thermo Fisher Scientific TRAIL-R2 (DR5) Monoclonal Antibody (DR5-01-1), FITC
TRAIL-R2 (DR5) 단백질의 세포 표면 발현을 검출하는 FITC 결합 단일클론 항체. 인간 시료 반응성, Flow Cytometry에 최적화. 액상 형태로 제공되며 4°C 암조건 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific TRAIL-R2 (DR5) Monoclonal Antibody (DR5-01-1), FITC
Applications
- Flow Cytometry (Flow): 1–5 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DR5-01-1 |
| Immunogen | Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955204 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily members that contain a death domain for TRAIL (APO2L).
Target Information
DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a death domain-containing receptor for TRAIL, mediating TRAIL-induced apoptosis.
It belongs to the TNF-receptor superfamily and transduces apoptosis signals via TNFSF10/TRAIL/APO-2L.
Two transcript variants encoding different isoforms and one non-coding transcript have been identified.
Overexpression of DR5 induces apoptosis and activates NF-κB. DR5 is highly expressed in lymphocytes and spleen.
Diseases associated with DR5 dysfunction include squamous cell carcinoma and diffuse infiltrative lymphocytosis syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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