Thermo Fisher Scientific Phospho-Dynamin 1 (Ser774) Polyclonal Antibody
Phospho-Dynamin 1 (Ser774) 폴리클로날 항체로서 신경세포 내 Dynamin 단백질의 인산화 상태를 검출. Western blot, IHC, ICC에 사용 가능. 양, IgG 호스트 기반 항체로 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 1:1,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser774 of rat DNM1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560610 |
Product Specific Information
This antibody is predicted to react with bovine, canine, chicken, human, mouse, and non-human primate based on 100% sequence homology.
It does not cross-react with other purified substrates of cdk5 (amphiphysin and synapsin).
This antibody is specific for the ~95 kDa Dynamin protein phosphorylated at Ser774 in Western blots of rat brain lysates.
It labels the purified protein phosphorylated in vitro by cdk5 but not by PKC.
Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
Store at -20ºC for short term, -80ºC for long term storage.
Target Information
Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane.
Its involvement in endocytosis was first discovered in Drosophila melanogaster through the shibire mutation.
Three isoforms exist in mammals: Dynamin1 (neuronal), Dynamin2 (ubiquitous), and Dynamin3 (testes).
Each isoform has splice variants suggesting distinct intracellular targets or vesicle functions.
Common domain features include:
- N-terminal GTPase domain
- Central pleckstrin homology domain
- Proline-rich C-terminal with multiple SH3 domains
These SH3 domains target dynamin to clathrin-coated pits.
Dynamin interacts with AP2 adaptor protein complex and amphiphysin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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