Thermo Fisher Scientific ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9T3M5

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Erlin-2 (O94905). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ERLIN2,uniProtId:O94905-1,ncbiNodeId:9606,antigenRange:50-150,antigenLength:339,antigenImageFileName:MA5-42625_ERLIN2_O94905-1_Rabbit.svg,antigenImageFileNamePDP:MA5-42625_ERLIN2_O94905-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911766

Product Specific Information

Positive test controls include: 293T, PC-3, OVCAR3, C2C12. The target is usually found in the following locations: Endoplasmic reticulum membrane, Single-pass type II membrane protein.

Immunogen sequence: HLMLPFITSY KSVQTTLQTD EVKNVPCGTS GGVMIYFDRI EVVNFLVPNA VYDIVKNYTA DYDKALIFNK IHHELNQFCS VHTLQEVYIE LFDQIDENLK L

Target Information

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.