Thermo Fisher Scientific ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)
ERLIN2 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, WB, IHC, ELISA에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며 HEK293 세포에서 발현되었습니다. 고순도 친화 크로마토그래피 정제, PBS/glycerol 버퍼에 보관됩니다.
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Thermo Fisher Scientific ERLIN2 Recombinant Rabbit Monoclonal Antibody (9T3M5)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9T3M5 |
| Immunogen | A synthetic peptide corresponding to amino acids 50–150 of human Erlin-2 (O94905) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911766 |
Product Specific Information
Positive test controls include: 293T, PC-3, OVCAR3, C2C12.
The target is typically localized to the endoplasmic reticulum membrane and is a single-pass type II membrane protein.
Immunogen sequence:
HLMLPFITSY KSVQTTLQTD EVKNVPCGTS GGVMIYFDRI EVVNFLVPNA VYDIVKNYTA DYDKALIFNK IHHELNQFCS VHTLQEVYIE LFDQIDENLK L
Target Information
ERLIN2 (also known as C8orf2, SPFH2) is a component of the ERLIN1/ERLIN2 complex that mediates ER-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.
It promotes sterol-accelerated ERAD of HMGCR, likely involving an AMFR/gp78 ubiquitin ligase complex.
ERLIN2 regulates cellular cholesterol homeostasis via the SREBP signaling pathway.
The molecular weight of the ERLIN1/ERLIN2 complex is approximately 70 kDa.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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