Thermo Fisher Scientific PKR Polyclonal Antibody
PKR 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western blot 및 ICC/IF에 적합합니다. 인간 및 마우스 시료에서 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 제공되며 연구용으로만 사용됩니다.
- 카탈로그번호
- PA1990
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific PKR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues L(435) V T S L K N D G K R T R S K (449) of human PKR |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_560651 |
Product Specific Information
PA1-990 detects PKR in human and mouse samples.
It has been successfully used in Western blot and ICC/IF procedures.
In Western blot analysis of HeLa cell cytosol, this antibody detects a ~66 kDa protein representing PKR.
The PA1-990 immunogen is a synthetic peptide corresponding to residues L(435) V T S L K N D G K R T R S K (449) of human PKR.
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses.
PKR plays a key role in antiviral defense mediated through its activation by double-stranded RNA produced during viral infection.
It is involved in IFN-induced innate antiviral response, virus-induced apoptosis, cell growth, and differentiation.
PKR regulates multiple pathways including NF-κB activation, p53, p38, and PDGF signaling, and has been implicated in tumor suppression and malignancy.
Viruses may inhibit PKR activity through mechanisms such as NS1 protein of influenza virus.
Recent studies link PKR to neurodegenerative diseases including Alzheimer’s, Huntington’s, and ALS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA1-990_PKR_P19525-1_Rabbit.svg, PA1-990_PKR_P19525-1_Rabbit_PDP.jpeg)
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