Thermo Fisher Scientific HIF3A Polyclonal Antibody, DyLight 550
HIF3A 단백질을 인식하는 DyLight 550 형광 표지 폴리클로날 항체입니다. Western blot에 적합하며, 556/570 nm의 형광 특성을 가집니다. 인간 HIF-3α N-말단을 면역원으로 사용하였으며, 세포 저산소 반응 연구에 활용됩니다.
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Thermo Fisher Scientific HIF3A Polyclonal Antibody, DyLight 550
Applications
- Western Blot (WB)
Tested Dilution: 1:100–1:200
Suggested Positive Control: Reticulocyte lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Bacterially expressed human HIF-3 alpha (N-terminus) |
| Conjugate | DyLight™ 550 |
| Excitation / Emission Max | 556 / 570 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_11152978 |
Target Information
Cell growth and viability are compromised by oxygen deprivation (hypoxia).
Hypoxia-inducible factors (HIFs), including HIF-1α, HIF-1β (Arnt 1), EPAS-1 (HIF-2α), and HIF-3α, regulate glycolysis, erythropoiesis, and angiogenesis to restore oxygen homeostasis.
These factors belong to the Per-Arnt-Sim (PAS) domain transcription factor family.
Under hypoxia, HIF-1α is upregulated and forms a heterodimer with Arnt 1 to create the HIF-1 complex, which binds to hypoxia-responsive elements (HREs) in target genes to activate transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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