Thermo Fisher Scientific beta Tubulin Monoclonal Antibody (TU-06)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody recognizes all beta-tubulin isoforms in various species.
Suitable for immunocytochemistry using fixed and permeabilized cells.

Target Information

Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance, and maintenance.
Mutations in the beta tubulin gene can cause congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin is also detected in Sertoli cells and transiently in non-neuronal embryonic tissues.
Glutamate residues at the C-terminus of beta III tubulin can be glutamylated; the functional significance of this modification remains unclear.
Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression, inhibiting incorporation into microtubules.
Microtubules are key cytoskeletal components essential for chromosome segregation, intracellular transport, and structural support.
Because beta-tubulin is ubiquitously expressed, it is often used as a loading control in protein detection assays such as Western blotting.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.