Thermo Fisher Scientific CD38 Monoclonal Antibody (6E12D)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15570 targets CD38 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The MA5-15570 immunogen is a purified recombinant fragment of human CD38 expressed in E. coli.
MA5-15570 detects CD38, which has a predicted molecular weight of approximately 34 kDa.

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase, or as a cell surface receptor.

Antibodies to CD38 are useful in:

• Subtyping of lymphomas and leukemias
• Detection of plasma cells (e.g., identification of myelomas)
• As a marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.