Thermo Fisher Scientific Phospho-TSC2 (Ser1387) Polyclonal Antibody
TSC2 단백질의 Ser1387 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 사람, 생쥐, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TSC2 (Accession P49815), corresponding to amino acid residues around phosphorylated Ser1387. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816150 |
Product Specific Information
This antibody detects endogenous levels of Tuberin/TSC2 only when phosphorylated at Ser1387.
Target Information
TSC2 (Tuberin, Tuberous sclerosis complex, TSC Complex Subunit 2) is implicated as a tumor suppressor and may function in vesicular transport, regulation of cell growth arrest, and transcription mediated by steroid receptors.
TSC2 associates with hamartin (TSC1) in a cytosolic complex, possibly acting as a chaperone. Phosphorylation on Ser939 and Thr1462 regulates its interaction with hamartin, stimulated by growth factors via the PI3K/Akt pathway.
TSC2 stimulates the intrinsic GTPase activity of RAP1A and RAB5, suggesting a role in regulating cellular growth. Mutations in TSC2 are associated with diseases such as lymphangioleiomyomatosis and TSC2 angiomyolipoma.
Alternative splicing results in three transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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