Thermo Fisher Scientific CD22 Monoclonal Antibody (IS7), FITC
CD22 단백질을 인식하는 마우스 단클론 항체(FITC 결합형)로, 인간 B세포 표면 발현 분석에 적합합니다. Flow Cytometry에 사용되며, 498/517 nm 형광 특성을 가집니다. 액상 형태로 제공되며 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IS7 |
| Immunogen | Reh human cell line |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154156 |
Additional Formats
Product Specific Information
This antibody reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes. It is lost on plasma cells, peripheral blood T lymphocytes, granulocytes, and monocytes.
Target Information
CD22 (BL-CAM) is a type I integral membrane glycoprotein (130–140 kDa) expressed in both cytoplasm and membrane of B-lymphocytes. It appears early in B-cell differentiation, similar to CD19. CD22 membrane expression is limited to mature B cells (CD22⁺) and lost in plasma cells (CD22⁻), useful for phenotyping mature leukemias. Strongly expressed in hairy cell leukemia, and positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.
CD22 preferentially binds α2,6-linked sialic acid. Ligand-induced tyrosine phosphorylation suggests a regulatory role in B-cell receptor signaling, acting as both a positive regulator via Src kinases and an inhibitory receptor through recruitment of cytoplasmic phosphatases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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