Thermo Fisher Scientific NALCN Monoclonal Antibody (N187/7), FITC
NALCN 단백질을 검출하기 위한 FITC 결합 단클론 항체로, 인간·마우스·랫트 반응성을 보입니다. WB 및 ICC/IF에 사용 가능하며, 498/517nm 형광 특성을 가집니다. Protein G로 정제된 액상 형태로 4°C 암소 보관합니다.
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Thermo Fisher Scientific NALCN Monoclonal Antibody (N187/7), FITC
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N187/7 |
| Immunogen | Fusion protein amino acids 1659–1738 (cytoplasmic C-terminus) of rat NALCN |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932027 |
Additional Formats
- Unconjugated (MA5-27593)
- APC (MA5-45572)
- PE (MA5-45575)
- PerCP (MA5-45574)
- Request custom conjugation
Product Specific Information
- 1 µg/mL of MA5-45573 was sufficient for detection of NALCN in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Detects approximately 200 kDa.
- This antibody was formerly sold as clone S187-7.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to sodium, potassium, and calcium ions. It regulates resting membrane potential and neuronal excitability. Neuropeptides such as neurotensin and substance P activate NALCN through SRC family kinases-dependent pathways. Nalcn is essential for normal respiratory rhythm, neonatal survival, and systemic osmoregulation. It contributes to spontaneous firing and excitability modulation in substantia nigra pars reticulata neurons.
Diseases associated with NALCN include congenital contractures of limbs and face, hypotonia, developmental delay, and infantile psychomotor retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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