Thermo Fisher Scientific PDE2A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 20 µg/mL

Product Specifications

Product Specific Information

• Percent identity with other species (BLAST analysis):
  Human, Gorilla, Marmoset, Dog, Panda, Horse (100%);
  Gibbon, Monkey, Mouse, Rat, Bovine, Elephant, Rabbit (94%);
  Pig (88%).

• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides should be incubated with a biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE).
Three isoforms (PDE2A1, PDE2A2, PDE2A3) arise from a single gene via alternative splicing.
PDE2A degrades both cAMP and cGMP, with higher efficacy for cGMP.
It is expressed in various tissues, with the highest levels in the brain (cerebellum and neocortex).
PDE2A has been implicated in penile erectile dysfunction and in regulating fluid and inflammatory cell transport across the endothelial barrier.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.