Thermo Fisher Scientific PDE6A Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 10–15 µg/mL
• 참고: For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:

• 100%: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster
• 94%: Dog, Panda, Rabbit
• 89%: Bovine, Bat, Elephant
• 83%: Horse, Opossum

Target Information

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits.
cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis.
The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal.
Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.