Thermo Fisher Scientific PDE6A Polyclonal Antibody
PDE6A 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 등 다양한 응용에 적합합니다. Human, Mouse, Rat 등 다종 반응성을 가지며, 항원 친화 크로마토그래피로 정제되었습니다. 시료는 PBS 용액 내에 0.1% sodium azide를 포함하고 있습니다.
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- PA532974
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- pk
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 10–15 µg/mL
- 참고: For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from N-terminus of human PDE6A / PDE6 Alpha |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.23 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550435 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- 100%: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster
- 94%: Dog, Panda, Rabbit
- 89%: Bovine, Bat, Elephant
- 83%: Horse, Opossum
Target Information
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits.
cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis.
The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal.
Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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