Thermo Fisher Scientific Kir6.2 (KCNJ11) Polyclonal Antibody
Kir6.2(KCNJ11) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. WB, IHC, ICC/IF에 사용 가능하며, 인간·마우스·랫트 반응성. 액상 형태로, -20°C 보관 및 Affinity chromatography로 정제됨.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KCNJ11 (Accession Q14654), corresponding to amino acid residues L200–F250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818373 |
Product Specific Information
Antibody detects endogenous levels of total Kir6.2.
Target Information
This receptor is controlled by G proteins. Inward rectifier potassium channels allow potassium to flow into the cell more readily than out of it. Their voltage dependence is regulated by extracellular potassium concentration; as external potassium increases, the voltage range for channel opening shifts to more positive voltages. Inward rectification is mainly due to blockage of outward current by internal magnesium and can be blocked by extracellular barium. Kir6.2 (KCNJ11) is a subunit of ATP-sensitive potassium channels (KATP) and can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore, while ABCC9 is required for activation and regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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