Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (8516), PE

Applications

Immunocytochemistry (ICC/IF)

• Tested dilution: 정보 없음
• Publications: View 1 publication

Flow Cytometry (Flow)

• Recommended usage: 10 µL per million cells
• Publications: View 1 publication

Product Specifications

Additional Formats

• APC
• FITC
• Request custom conjugation

Product Specific Information

This antibody shows less than 5% cross-reactivity with recombinant mouse (rm) IL-1 beta and recombinant porcine IL-1 beta, and no cross-reactivity with recombinant rat (rr) IL-1 beta, rmIL-1 alpha, recombinant human IL-1ra, rmIL-1ra, or rrIL-1 alpha.

Target Information

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa protein by caspase-1 following inflammasome activation. IL-1 beta lacks a signal peptide for classical secretion and is released through an alternate pathway. It signals through IL-1RI and IL-1RII receptors and is regulated by IL-1 Receptor Antagonist (IL-1RA). Elevated IL-1 beta levels are associated with chronic inflammatory conditions and may have therapeutic significance when neutralized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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