Thermo Fisher Scientific IL-1 beta Monoclonal Antibody (8516), PE
인간 IL-1 beta를 인식하는 마우스 단클론 항체로 PE 형광 표지됨. Flow Cytometry 및 ICC/IF에 적합. 낮은 교차 반응성으로 높은 특이성 제공. 단백질 A/G 정제, 4°C 암소 보관. 연구용 전용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested dilution: 정보 없음
- Publications: View 1 publication
Flow Cytometry (Flow)
- Recommended usage: 10 µL per million cells
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8516 |
| Immunogen | E. coli-derived recombinant human IL-1 beta/IL-1F2 (aa 117–269) |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | Buffered saline solution with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609797 |
Additional Formats
Product Specific Information
This antibody shows less than 5% cross-reactivity with recombinant mouse (rm) IL-1 beta and recombinant porcine IL-1 beta, and no cross-reactivity with recombinant rat (rr) IL-1 beta, rmIL-1 alpha, recombinant human IL-1ra, rmIL-1ra, or rrIL-1 alpha.
Target Information
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into the active 17 kDa protein by caspase-1 following inflammasome activation. IL-1 beta lacks a signal peptide for classical secretion and is released through an alternate pathway. It signals through IL-1RI and IL-1RII receptors and is regulated by IL-1 Receptor Antagonist (IL-1RA). Elevated IL-1 beta levels are associated with chronic inflammatory conditions and may have therapeutic significance when neutralized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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