Thermo Fisher Scientific Podoplanin Monoclonal Antibody (8.1.1)
Podoplanin 단백질을 인식하는 Syrian hamster 유래 단클론 항체로, IHC, WB, Flow 등 다양한 응용에 적합합니다. 1 mg/mL 농도의 액상 형태이며 Protein G로 정제되었습니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Podoplanin Monoclonal Antibody (8.1.1)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 0.5–1 µg/mL | - |
| Flow Cytometry (Flow) | - | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Blocking Assay (BLOCK) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Syrian hamster / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8.1.1 |
| Immunogen | Thymic epithelial mouse cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539437 |
Product Specific Information
This target has a predicted molecular weight of 25 kDa.
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa.
It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells.
Podoplanin localizes in stromal cells of peripheral lymphoid tissues and thymic epithelial cells.
As a regulator of the lymphatic endothelium, podoplanin likely contributes to maintaining the unique shape of podocytes.
It serves as a ligand for CLEC-2, and its expression correlates with tumor invasiveness and metastatic potential.
Podoplanin participates in cell migration, metastasis formation, and tumor invasion.
Its expression can be induced through Src activation of Cas and has been observed on Th17 cells.
Studies indicate its presence in a distinct population of CD4+ cells from human PBMC.
Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottic neoplasm.
Additionally, it has been proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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