Thermo Fisher Scientific PD-L1/PDCD1LG1/CD274/B7-H1 (Cancer Immunotherapy Target) Monoclonal Antibody (PDL1/2746), PE
PD-L1 단백질을 표적으로 하는 항암 면역치료 연구용 Mouse monoclonal antibody. Human 및 Mouse 반응성. PE 형광 표지로 Flow Cytometry 및 Immunocytochemistry에 최적. 단백질 A/G 정제, PBS buffer 저장, 암 면역 회피 연구에 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PDL1/2746 |
| Immunogen | Recombinant fragment (around aa 39–191) of human CD274 (PD-L1) protein |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
Additional Formats
- Biotin conjugate available
- Custom conjugation upon request
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. PD-L1 binds to its receptor PD-1, which negatively regulates T-cell receptor (TCR) signaling. Upon ligation, PD-L1 decreases TCR-mediated proliferation and cytokine production. PD-L1 expression is abundant in many murine and human cancers and can be up-regulated by IFN-gamma stimulation, suggesting an important role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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