Thermo Fisher Scientific Phospho-TAK1 (Ser439) Polyclonal Antibody
TAK1 단백질의 Ser439 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF에 적합하며, 인간·생쥐·랫드 시료에 반응합니다. 고순도 정제 및 안정적인 PBS/glycerol 포맷으로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP3K7 (Accession O43318), corresponding to amino acid residues around phosphorylated Ser439. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816138 |
Product Specific Information
Antibody detects endogenous levels of TAK1 only when phosphorylated at Ser439.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. It interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38, and also participates in Wnt, BMP, and activin signaling. TAK1 regulates wound healing by promoting von Hippel-Lindau tumor suppressor expression and repressing PDGF-B and integrins. It plays a key role in IKK activation through IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I pathways. Activation involves TAB2/3 binding and polyubiquitination, followed by TAK1 autophosphorylation at Thr178, Thr184, Thr187, and Ser192, leading to IKK-β phosphorylation. TAK1 also represses human telomerase reverse transcriptase, suggesting a role in cell lifespan regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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