Thermo Fisher Scientific Optineurin Polyclonal Antibody
Optineurin 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. Human에 반응하며 항원 친화 크로마토그래피로 정제됨. PBS 버퍼(40% glycerol) 내 액상 형태로 제공되며, 연구용으로만 사용.
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- PA551882
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Optineurin (Product #RP-101057) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644993 |
Product Specific Information
Immunogen sequence:
LELAEKALAS KQLQMDEMKQ TIAKQEEDLE TMTILRAQME VYCSDFHAER AAREKIHEEK EQLALQLAVL LKENDAFEDG GRQSLMEMQS RHGARTSDSD QQAYLVQRGA EDRDWRQQRN IPIHSCPKCG EVL
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 88%
Target Information
The OPTN gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open-angle glaucoma. It interacts with adenovirus E3-14.7K protein and may utilize TNF-alpha or Fas-ligand pathways to mediate apoptosis, inflammation, or vasoconstriction. Optineurin is also involved in cellular morphogenesis, membrane and vesicle trafficking, and transcription activation through interactions with RAB8, huntingtin, and transcription factor IIIA.
Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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