Thermo Fisher Scientific WSB1 Polyclonal Antibody
Human WSB1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 적합. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 용액 형태. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PA551884
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human WSB1 (Product #RP-102067) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649665 |
Product Specific Information
Immunogen sequence:
APFDKKCGRE NWTVAFAPDG SYFAWSQGHR TVKLVPWSQC LQNFLLHGTK NVTNSSSLRL PRQNSDGGQK NKPREHIIDC GDIVWSLAFG SSVPEKQSRC VNIEWHRFRF GQDQLLLATG LNNGRIKIWD V
Ortholog sequence identity:
- Mouse: 91%
- Rat: 93%
Target Information
WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein containing one SOCS box domain and six WD repeats. It is expressed as multiple alternatively spliced isoforms and functions as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates ubiquitination and proteasomal degradation of target proteins such as DIO2.
Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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