Thermo Fisher Scientific WSB1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human WSB1. Recombinant protein control fragment (Product #RP-102067). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:WSB1,uniProtId:Q9Y6I7-1,ncbiNodeId:9606,antigenRange:27-157,antigenLength:421,antigenImageFileName:PA5-51884_WSB1_Q9Y6I7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51884_WSB1_Q9Y6I7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649665

Product Specific Information

Immunogen sequence: APFDKKCGRE NWTVAFAPDG SYFAWSQGHR TVKLVPWSQC LQNFLLHGTK NVTNSSSLRL PRQNSDGGQK NKPREHIIDC GDIVWSLAFG SSVPEKQSRC VNIEWHRFRF GQDQLLLATG LNNGRIKIWD V

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 93%.

Target Information

WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.