Thermo Fisher Scientific CD2AP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CD2AP. Recombinant protein control fragment (Product #RP-101069). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD2AP,uniProtId:Q9Y5K6-1,ncbiNodeId:9606,antigenRange:146-272,antigenLength:639,antigenImageFileName:PA5-51879_CD2AP_Q9Y5K6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51879_CD2AP_Q9Y5K6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.10 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2639537

Product Specific Information

Immunogen sequence: WSGTLNNKLG LFPSNFVKEL EVTDDGETHE AQDDSETVLA GPTSPIPSLG NVSETASGSV TQPKKIRGIG FGDIFKEGSV KLRTRTSSSE TEEKKPEKPL ILQSLGPKTQ SVEITKTDTE GKIKAKE

Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 83%.

Target Information

This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.