Thermo Fisher Scientific CD2AP Polyclonal Antibody
CD2AP 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CD2AP. Recombinant protein control fragment (Product #RP-101069). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639537 |
Product Specific Information
Immunogen sequence:
WSGTLNNKLG LFPSNFVKEL EVTDDGETHE AQDDSETVLA GPTSPIPSLG NVSETASGSV TQPKKIRGIG FGDIFKEGSV KLRTRTSSSE TEEKKPEKPL ILQSLGPKTQ SVEITKTDTE GKIKAKE
- Highest antigen sequence identity to orthologs:
- Mouse: 82%
- Rat: 83%
Target Information
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein interacts with filamentous actin and various cell membrane proteins via multiple actin-binding sites, SH3 domains, and a proline-rich region. It localizes to membrane ruffles, lipid rafts, and leading cell edges, playing roles in actin remodeling and membrane trafficking during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is associated with susceptibility to glomerular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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