Thermo Fisher Scientific ARIH1 Polyclonal Antibody
Thermo Fisher Scientific의 ARIH1 Polyclonal Antibody는 인간 ARIH1 단백질을 인식하는 토끼 IgG 기반 항체로, IHC 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 버퍼에 보존되어 안정적입니다. 연구용으로만 사용됩니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: -
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ARIH1. Recombinant protein control fragment (Product #RP-102072) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638185 |
Product Specific Information
Immunogen sequence:
LQHMVECIRE VNEVIQNPAT ITRILLSHFN WDKEKLMERY FDGNLEKLFA ECHVINPSKK SRTRQMNTRS SAQDMPCQIC YLNYPNSYFT GLECGHKFCM QCWSEYLTTK IMEEGMGQTI SCPAHGCDIL VDDNTVMRLI TDSKVK
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
E3 ubiquitin-protein ligase that catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3.
Acts as an atypical E3 ubiquitin-protein ligase by working with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates.
Associates with CRL complexes and mediates addition of the first ubiquitin on CRL targets; elongation is then performed by CDC34/UBE2R1 and UBE2R2.
Activity is activated upon binding to neddylated CRL complexes.
Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, affecting cap-binding and translation regulation.
Also involved in ISGylation of EIF4E2 and regulation of LINC complex member SUN2, influencing nuclear morphology and localization.
[UniProt]
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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