Thermo Fisher Scientific JAK1 Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal JAK1 항체. Western blot에 적합하며, 세포질 위치의 JAK1 단백질 검출에 사용. 항원 친화 크로마토그래피로 정제된 액상 형태, 안정화제 포함 PBS 버퍼에 보관.
- 카탈로그번호
- 600-350
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from adjacent to C-terminus of JAK1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Skeletal muscle
- Cellular location: Cytoplasm
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli such as interferons and cytokines induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which then dimerize, translocate to the nucleus, and bind to upstream cis elements of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation. Phosphorylation at tyrosine residues 1022 and 1023 is believed to be critical for activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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