Thermo Fisher Scientific JAK1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

Product Specifications

Product Specific Information

• Positive control: Skeletal muscle
• Cellular location: Cytoplasm

Target Information

Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli such as interferons and cytokines induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 phosphorylates proximal Stat factors, which then dimerize, translocate to the nucleus, and bind to upstream cis elements of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation. Phosphorylation at tyrosine residues 1022 and 1023 is believed to be critical for activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.