Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (HMFG1 (1.10.F3))
MUC1 종양 관련 항원을 인식하는 재조합 마우스 단클론 항체로, 유방암 세포에 특이적으로 결합합니다. WB, IHC, ICC, ELISA 등 다양한 면역실험에 사용 가능하며, HEK293 세포에서 발현된 IgG1, kappa 형식의 항체입니다. 단백질 A 정제 및 1 mg/mL 농도로 제공됩니다.
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Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (HMFG1 (1.10.F3))
Applications and Tested Dilutions
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- Immunocytochemistry (ICC/IF): Assay-dependent
- ELISA: Assay-dependent
- Immunoprecipitation (IP): Assay-dependent
- Radioimmune Assays (RIA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | HMFG1 (1.10.F3) |
| Immunogen | Human mammary milk fat globule |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to MUC1, a tumor-associated antigen expressed on many breast cancer cells. It does not show reactivity towards fibroblasts, lymphoblastoid cells, or epithelial cell lines of non-breast origin. The antibody recognizes the PDTR epitope of mucin.
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is a transmembrane glycoprotein with a large extracellular domain containing numerous O-linked glycans. MUC1 is highly polymorphic, with each allele encoding a different number of tandem repeats (30–90), resulting in molecular weight variability.
MUC1 is abundantly expressed (>90%) in breast carcinomas and metastases. Overexpression, aberrant localization, and altered glycosylation are associated with carcinomas. Multiple alternatively spliced transcript variants exist, encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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