Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (HMFG1 (1.10.F3))

Thermo Fisher Scientific MUC1 Recombinant Mouse Monoclonal Antibody (HMFG1 (1.10.F3))

Applications and Tested Dilutions

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (IHC): Assay-dependent
• Immunocytochemistry (ICC/IF): Assay-dependent
• ELISA: Assay-dependent
• Immunoprecipitation (IP): Assay-dependent
• Radioimmune Assays (RIA): Assay-dependent

Product Specifications

Product Specific Information

This antibody binds to MUC1, a tumor-associated antigen expressed on many breast cancer cells. It does not show reactivity towards fibroblasts, lymphoblastoid cells, or epithelial cell lines of non-breast origin. The antibody recognizes the PDTR epitope of mucin.

Target Information

MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is a transmembrane glycoprotein with a large extracellular domain containing numerous O-linked glycans. MUC1 is highly polymorphic, with each allele encoding a different number of tandem repeats (30–90), resulting in molecular weight variability.

MUC1 is abundantly expressed (>90%) in breast carcinomas and metastases. Overexpression, aberrant localization, and altered glycosylation are associated with carcinomas. Multiple alternatively spliced transcript variants exist, encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.