Thermo Fisher Scientific WDR5 Recombinant Human Monoclonal Antibody (RAB-C223)
WDR5 단백질을 인식하는 인간 재조합 단일클론 항체로, ICC/IF, Flow, ELISA, IP, ChIP 등 다양한 응용에 사용 가능. HEK293 세포에서 발현된 F(ab) 형식의 항체이며, 금속-킬레이트 크로마토그래피로 정제됨. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C223 |
| Immunogen | This antibody was obtained by recombinant antibody (rAb) phage display recognizing WDR5 protein under non-denaturing conditions. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody recognizes WDR5 (WD repeat-containing protein 5). It binds to a folded domain, amino acids 1–334. WDR5 is a protein involved in histone modification.
Target Information
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes.
Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruitment of EGLN1/PHD2 to the HSP90 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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