Thermo Fisher Scientific HDAC4 Recombinant Rabbit Monoclonal Antibody (14H4L10)

Thermo Fisher Scientific HDAC4 Recombinant Rabbit Monoclonal Antibody (14H4L10)

Applications and Tested Dilution

• Western Blot (WB): 1–2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Rat, Pig, and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening of individual clones to select optimal candidates for production.
Advantages include:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of core histones (H2A, H2B, H3, and H4).
Histone deacetylation acts as an epigenetic repression marker and plays an important role in transcriptional regulation, cell cycle progression, and developmental events.
HDAC4 functions within large multiprotein complexes and is involved in muscle maturation through interactions with MEF2A, MEF2C, and MEF2D.
It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene have been associated with Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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