Thermo Fisher Scientific IRF8 Recombinant Rabbit Monoclonal Antibody (24H13L20)
IRF8 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 면역세포염색에 사용 가능. 높은 특이성과 재현성을 제공하며, Expi293 시스템에서 생산된 동물 유래 성분 무첨가 항체. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Hamster |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 24H13L20 |
| Immunogen | Peptides corresponding to Human IRF8 (aa 261–277, 411–426) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633084 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, and Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in these systems. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
Target Information
IRF8 (Interferon Regulatory Factor 8) is a transcriptional activator or repressor that binds to upstream regulatory regions of type I IFN and IFN-inducible MHC class I genes.
It plays a negative regulatory role in immune cells and is involved in CD8⁺ dendritic cell differentiation by forming complexes with BATF-JUNB heterodimers, recognizing AICE sequences, and activating immune-related genes.
Mutations in this gene can cause immunodeficiency 32A and 32B.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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