Thermo Fisher Scientific DERL2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human DERL2. Recombinant protein control fragment (Product #RP-101719). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DERL2,uniProtId:Q9GZP9-1,ncbiNodeId:9606,antigenRange:195-217,antigenLength:239,antigenImageFileName:PA5-63318_DERL2_Q9GZP9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-63318_DERL2_Q9GZP9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640534

Product Specific Information

Immunogen sequence: GIRILKTPSI LKAIFDTPDE DPN

Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

Target Information

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.