Thermo Fisher Scientific ELOVL1 Polyclonal Antibody
Human ELOVL1 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P)와 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제. PBS 및 글리세롤 완충액에 보관. 장기 보관 시 -20°C에서 냉동 보관 권장.
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- PA563320
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ELOVL1. Recombinant protein control fragment (Product # RP-103262) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640999 |
Product Specific Information
- Immunogen sequence: FWYHSYTKGK RLPRALQQNG APGIAKVK
- Highest antigen sequence identity to orthologs: Mouse – 86%, Rat – 82%
Target Information
Elongation of very long chain fatty acid-like (ELOVL) proteins 1–6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids.
ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER).
ELOVL1 (also referred to as Ssc1) is the human homolog of the yeast ELO3 protein. It is expressed in various tissues, with high levels in stomach, skin, intestine, kidney, and lung.
ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acids (up to 26 carbons) and may be required for epithelial and skin barrier development.
It is also important for myelin formation in the central nervous system. Impaired ELOVL1 activity may be associated with sphingolipid metabolism disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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