Thermo Fisher Scientific Tyrosine Hydroxylase Monoclonal Antibody (CL3049)
Tyrosine Hydroxylase 단백질을 표적하는 Mouse Monoclonal Antibody(CL3049). Human, Mouse, Rat 시료에 반응하며 IHC(P)에서 1:500~1:1000 희석으로 사용 가능. Protein A 정제, PBS buffer에 40% glycerol 포함. 신경전달물질 합성 연구용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL3049 |
| Immunogen | Recombinant protein corresponding to Human Tyrosine Hydroxylase (range: 465–528, length: 528 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848914 |
Product Specific Information
Immunogen sequence:
SESFSDAKDK LRSYASRIQR PFSVKFDPYT LAIDVLDSPQ AVRRSLEGVQ DELDTLAHAL SAIG
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. Catecholamine synthesis is regulated by the interaction of TH with tetrahydrobiopterin (BH4), which binds to the catalytic domain of TH and activates the enzyme.
In humans, four TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains while sharing identical catalytic domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a crucial role in adrenergic neuron physiology.
TH activity is associated with neuropathogenic diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and various cardiovascular disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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