Thermo Fisher Scientific CRYAB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK
• Positive Samples: U-87MG, 293T, A-549, Mouse brain, Mouse heart, Mouse kidney, Mouse lung, Rat heart
• Cellular Location: Cytoplasm, Nucleus

Target Information

Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest, composed of alpha-A and alpha-B gene products. In addition to maintaining the refractive index, alpha-crystallin acts as a chaperone to prevent aggregation leading to cataract formation. Phosphorylated alpha-crystallin responds to cellular stress and may play a role in protein maintenance. Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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