Thermo Fisher Scientific RhoB Recombinant Rabbit Monoclonal Antibody (19H1L5)

Applications

Western Blot (WB)

• Tested Dilution: 1–2 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2 µg/mL

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, Goat, and Cat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Superior specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to diverse rabbit immune repertoire

Target Information

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. Although not essential for development, it influences cell adhesion and growth factor signaling in transformed cells.
RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. It is also required for the stability and nuclear trafficking of AKT1/AKT, promoting endothelial cell survival during vascular development.
RhoB serves as a tumor suppressor — deletion of RhoB can lead to tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.