Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1H2), TrueMAB
인간 ALK 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot 및 Luminex 분석에 적합합니다. 무보존제, 동결건조 형태이며 재구성 후 1 mg/mL 농도로 사용 가능합니다. 뇌 발달 및 종양 관련 ALK 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Luminex (LUM)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is essential for brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement between ALK (chromosome 2) and NPM (chromosome 5) forms the oncogenic NPM-ALK fusion gene.
ALK shows high sequence similarity to LTK and plays a critical role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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