Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1F1), TrueMAB
ALK 단백질을 표적하는 마우스 모노클로날 항체로, Western blot 및 Luminex 분석에 적합합니다. 인간 ALK 단백질의 1060–1620 아미노산 영역을 면역원으로 사용하였으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with several tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements often lead to a fusion gene (NPM-ALK), which produces an oncogenic protein.
ALK is a novel receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
Its function is crucial for neuronal development and signaling in the nervous system.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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