Thermo Fisher Scientific ALK Monoclonal Antibody (OTI6G8), TrueMAB
인간 ALK 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 시 1 mg/mL 농도로 사용 가능합니다. 뇌 발달 관련 연구 및 ALK 관련 암 연구용으로 적합합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) is a member of the insulin receptor superfamily and plays a critical role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene are associated with various tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangements often generate a fusion gene combining ALK (chromosome 2) and NPM (chromosome 5), producing the oncogenic NPM-ALK fusion protein.
ALK is a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK, and functions in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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