Thermo Fisher Scientific Ganglioside GM2 Recombinant Human Monoclonal Antibody (L55-81)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

Assay-dependent

-

ELISA (ELISA)

Assay-dependent

-

Functional Assay (Functional)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Human / IgM, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

L55-81

Immunogen

L55-81 was prepared by isolating EBV-immortalized peripheral blood B lymphocytes from a human donor with melanoma.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

L55-81 binds specifically to GM2 ganglioside; this antibody shows no reactivity towards GM1, GM3, GD2 or normal tissues- the L55-81 epitope contains both a GalNAc and sialic acid bound to lactose. Ganglioside GM2 (GalNAc Beta 1-4(NeuNAc alpha 2-3)Gal Beta 1-4Glc Beta -1ceramide) is a glycosphingolipid present on the cell surface and a major tumor-differentiation antigen in human melanoma and hepatoma.

Target Information

Ganglioside GM2 is a glycosphingolipid found in the plasma membrane of cells, particularly in the nervous system. It is composed of a ceramide lipid tail and a complex carbohydrate head group that contains sialic acid residues. The function of Ganglioside GM2 is not fully understood, but it is believed to play a role in cell signaling and communication, as well as in the formation and maintenance of the myelin sheath that surrounds nerve cells. Mutations in the genes responsible for the synthesis or degradation of Ganglioside GM2 can result in various neurological disorders, including Tay-Sachs disease and Sandhoff disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.