Thermo Fisher Scientific GABRA1/GABRB1/GABRG2 Recombinant Mouse Monoclonal Antibody (1F4)
GABA-A 수용체의 α1β2γ2 복합체를 인식하는 마우스 단클론 항체. 인간 시료에 반응하며 HEK293 세포에서 발현된 재조합 항체. 단백질 A로 정제된 액상형 제품으로, 신경계 억제 신호 연구에 적합. 연구용으로만 사용 가능.
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Applications
- In vitro Assay (IV): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1F4 |
| Immunogen | This antibody was raised against alpha1β2γ2 GABA-A receptor. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes the alpha1β2γ2 GABA-A receptor, which is found in up to 50% of synapses in the brain. Its ligand, GABA, is a major inhibitory neurotransmitter that binds to this receptor and opens a chloride-permeable channel. Dysfunctions of GABA-A receptors are associated with anxiety, neurodevelopmental disorders, and epilepsy.
Target Information
The genes GABRA1, GABRB1, and GABRG2 are essential for the formation and function of GABA-A receptors, maintaining the balance between excitatory and inhibitory signals in the brain. Dysregulation or mutations in these genes can lead to neurological disorders and altered brain function. Understanding these genes provides insights into the mechanisms of such disorders and supports the development of targeted therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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