Thermo Fisher Scientific GABRA1/GABRB1/GABRG2 Recombinant Mouse Monoclonal Antibody (1F4)

Applications

Tested Dilution

Publications

In vitro Assay (IV)

Assay-dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1F4

Immunogen

This antibody was raised against alpha1β2γ2 GABA-A receptor.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

This antibody recognises alpha 1 Beta 2Gamma2 GABA-A receptor which is found in up to 50% of the synapses in the brain. It`s ligand, GABA is a major inhibitory transmitter in the nervous system, binds to this receptor and opens a channel permeable to chloride. Disfunctions of GABAR are found in anxiety, neurodevelopmental disorderds and epilepsy.

Target Information

These three genes, GABRA1, GABRB1, and GABRG2, play important roles in the formation and functioning of GABA-A receptors, which are critical for maintaining the balance between excitatory and inhibitory signals in the brain. Dysregulation or alterations in these genes can contribute to neurological disorders and impact brain function. Understanding the functions and variations in these genes can provide insights into the underlying mechanisms of these disorders and potentially aid in the development of targeted therapies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.