Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Monoclonal Antibody (PDCD1/7125)
PDCD1/PD1/CD279 단백질을 인식하는 마우스 단클론 항체. 인체 시료에 반응하며 IHC 및 ELISA 분석에 적합. Protein A/G로 정제된 액상 형태로 제공되며, 보존제 미첨가. 면역억제 수용체 PD-1 연구용으로 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PDCD1/7125 |
| Immunogen | Recombinant fragment (around aa1–200) of human PDCD1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two ligands, PDL-1 and PDL-2. Upon binding, PD-1 signaling inhibits immune activation in the absence of danger signals such as LPS.
PD1 knockout mice exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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