Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Monoclonal Antibody (PDCD1/7125)

Applications and Tested Dilutions

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC.
PD-1 binds two ligands, PDL-1 and PDL-2. Upon binding, PD-1 signaling inhibits immune activation in the absence of danger signals such as LPS.
PD1 knockout mice exhibit hyperactivated immune systems and autoimmune diseases.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.