Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Monoclonal Antibody (PDCD1/922)
인간 PD-1(CD279)을 인식하는 Mouse monoclonal antibody로, IHC, ICC/IF, Flow Cytometry에 사용 가능. Protein A/G로 정제된 액상형 항체이며, 보존제 무첨가. 면역조직학 및 세포면역분석 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PDCD1/922 |
| Immunogen | Recombinant full-length human PDCD1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express inhibitory receptors such as PD-1 (PDCD-1). PD-1 binds to ligands PDL-1 and PDL-2, transmitting inhibitory signals that regulate immune activation in the absence of danger signals. PD-1 deficiency in mice leads to hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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