Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody
Caveolin-1 단백질을 인식하는 염소 유래 polyclonal 항체로, Western blot, IHC, ICC, Flow Cytometry에 사용 가능. 인간에 반응하며, 다른 종에서도 예측 반응. 0.5 mg/mL 농도의 액상형 항체로 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.001–0.01 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Internal sequence corresponding to amino acids C-DELSEKQVYDAH (aa 34–46) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1071037 |
Product Specific Information
- Predicted to react with canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and regulates their activity. Caveolin-1 is involved in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated T-cell activation. It can bind with DPP4, inducing T-cell proliferation and NF-kappa-B activation in a TCR/CD3-dependent manner. Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, and partial lipodystrophy/congenital cataracts with neurodegeneration syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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