Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3694)
인체 TPO 단백질을 인식하는 Mouse IgG1 단일클론 항체로, IHC 및 Peptide Array에 적합합니다. 고순도 Protein A/G 정제, PBS 버퍼에 보존제 없이 제공되며 -20°C 이하에서 안정적으로 보관됩니다. 갑상선 관련 연구용으로 최적화된 항체입니다.
- 카탈로그번호
- 7173-MSM4-P1ABX
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Thermo Fisher Scientific TPO (Thyroid Peroxidase) Monoclonal Antibody (TPO, 3694)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TPO, 3694 |
| Immunogen | Recombinant fragment of human TPO (around aa 685–804) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Thyroid Peroxidase (TPO) is a membrane-bound glycoprotein enzyme crucial for thyroid gland function. It catalyzes iodination of tyrosine residues in thyroglobulin and facilitates the formation of thyroid hormones (thyroxine and triiodothyronine).
Mutations in TPO are associated with disorders such as congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Several transcript variants exist, though not all are fully characterized.
Diseases associated with TPO include Thyroid Dyshormonogenesis 2A and Congenital Hypothyroidism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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