Thermo Fisher Scientific SR-BI Polyclonal Antibody
SR-BI 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용(WB, IHC, ICC, Flow 등)에 사용 가능. 항원 친화 크로마토그래피로 정제된 고품질 항체. HDL 관련 콜레스테롤 대사 연구에 적합.
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Thermo Fisher Scientific SR-BI Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 |
| Flow Cytometry (Flow) | 1:400 |
| Immunoprecipitation (IP) | 1:10–1:500 |
| Neutralization (Neu) | Assay-Dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Bovine, Hamster, Human, Mustelid, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A C-terminal peptide containing residues 450–509 from mouse SR-BI (Uniprot: Q61009) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2182695 |
Product Specific Information
Suggested positive control: mouse liver lysate or protein.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. It is expressed primarily in liver and nonplacental steroidogenic tissues and mediates selective cholesterol uptake by a distinct mechanism.
In mice, SR-BI plays a key role in determining plasma lipoprotein cholesterol levels and cholesterol accumulation in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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